作者：Fang Li, Yang Shen, Qun Chen, Xingyu Li, Hongnan Yang, Canyang Zhang, Jinjun Lin, Zhicheng Du, Chenyao Jiang, Chengming Yang, Dongmei Yu, Peiwu Qin
關鍵詞：Ketogenic diet; Type 2 diabetes; Diabetic physiological parameters; MRI images; Offset of Oral Gluco
內容：Diet plays an important role in diabetes development. The effect of ketogenic diet on type 2 diabetes remains elusive. In this study, we collect diabetes related physiological parameters and abdominal MRI images to evaluate the effect of ketogenic diet after 3-months of consecutive treatment. Ketogenic diet mitigates the diabetes symptom inferring from the statistically significant reduction of key diabetic physiological parameters such as Hemoglobin A1c (HbA1c) concentration, Triglyceride (TG), Fasting blood glucose (FBG), Body Mass Index (BMI), and adipose tissue volume. Moreover, we propose a new parameter to quantify the treating effect of ketogenic diet since Slope and Offset of Oral Glucose Tolerance Test (SOOGTT) incorporate more sampling points by fitting OGTT (Oral Glucose Tolerance Test ) curve. SOOGTT shows statistically significant (P < 0.001) treating effect of ketogenic diet on type 2 diabetes. We use artificial intelligence to segment adipose tissue for treatment evaluation, which shows that ketogenic diet reduces the amount of adipose tissue.